MACDONALD LYNN,STEVENS SEAN,GURER CAGAN,MURPHY ANDREW J,HOSIAWA KAROLINA A
申请号：
IN106/CHENP/2013
公开号：
IN2013CN00106A
申请日:
2013.01.04
申请国别(地区):
IN
年份:
2016
代理人:
摘要：
Genetically modified mice are provided that express human variable (hV) sequences including mice that express hV sequences from an endogenous mouse light chain locus mice that express hV sequences from an endogenous mouse light chain locus and mice that express hVX sequences from a transgene or an episome wherein the hV sequence is linked to a mouse constant sequence. Mice are provided that are a source of somatically mutated human variable sequences useful for making antigen binding proteins. Compositions and methods for making antigen binding proteins that comprise human variable sequences including human antibodies are provided.
