MACDONALD, LYNN,STEVENS, SEAN,GURER, CAGAN,MURPHY, ANDREW, J.,HOSIAWA, KAROLINA, A.
申请号：
SG2012093266
公开号：
SG186391A1
申请日:
2011.06.22
申请国别(地区):
SG
年份:
2013
代理人:
摘要：
Genetically modified mice are provided that express human λ variable (hVλ) sequences, including mice that express hVλ sequences from an endogenous mouse λ light chain locus, mice that express hVλ sequences from an endogenous mouse κ light chain locus, and mice that express hVX sequences from a transgene or an episome wherein the hVλ, sequence is linked to a mouse constant sequence. Mice are provided that are a source of somatically mutated human λ variable sequences useful for making antigen- binding proteins. Compositions and methods for making antigen-binding proteins that comprise human λ variable sequences, including human antibodies, are provided.
