Macdonald, Lynn,Stevens, Sean,Gurer, Cagan,Murphy, Andrew J.,Hosiawa, Karolina A.
申请号：
AU2015275242
公开号：
AU2015275242A1
申请日:
2015.12.22
申请国别(地区):
AU
年份:
2016
代理人:
摘要：
#$%^&*AU2015275242A120160121.pdf#####ABSTRACT Genetically modified mice are provided that express human X variable (hVX) sequences, including mice that express hVX sequences from an endogenous mouse X light chain locus, mice that express hVX sequences from an endogenous mouse K light chain locus, and mice that express hVX sequences from a transgene or an episome wherein the hVX sequence is linked to a mouse constant sequence. Mice are provided that are a source of somatically mutated human X variable sequences useful for making antigen-binding proteins. Compositions and methods for making antigen-binding proteins that comprise human X variable sequences, including human antibodies, are provided.
