compound or a pharmaceutically acceptable salt thereof, pharmaceutical composition, use of a compound, and treatment methods for increasing androgenic activity in a patient, treatment for testosterone replacement or androgen supplementation in a patient, treatment of benign hypertrophy prostate (bph) in a patient and male contraception
DIRK LEYSEN,JAAP VAN DER LOUW,JOSEPH MARIA GERARDUS BARBARA CALS,MARCEL EVERT DE GOOIJER
申请号：
BRPI0611751
公开号：
BRPI0611751A2
申请日:
2006.06.16
申请国别(地区):
BR
年份:
2016
代理人:
摘要：
The invention provides for compounds having formula (1) wherein； R1 is O, (H,H), (H,OH), or NOR, with R being hydrogen, (C1-6) alkyl or (C1-6) acyl； R2 is hydrogen, methyl, ethyl, or ethenyl； R3 is hydrogen, methyl, ethyl, ethenyl, fluoro, or chloro； R4 is methyl, or ethyl； R5 is hydrogen, methyl, or ethyl； R6 is hydrogen, methyl, ethyl, (C1-3) alkenyl, or (C1-3) alkynyl； R7 is hydrogen or (C1-15) acyl； and at least one of R5 or R6 is hydrogen； or a pharmaceutically acceptable salt thereof, for use as medicine for a treatment to increase androgen levels, for androgen supplementation, for testosterone replacement and for benign prostate hypertrophy and in a method of male contraception, preferably as sole means to achieve both progestagenic sterilitant effect and androgen supplementation.
