Bhagwat Prasad,Abdul Basit,Haeyoung Zhang,John K. Amory
申请号：
US16380876
公开号：
US20190307773A1
申请日:
2019.04.10
申请国别(地区):
US
年份:
2019
代理人:
摘要：
Treatment of testosterone deficiency in men by a precision medicine approach using a biomarker of activity of UGT2B17 that is involved in testosterone urinary elimination. By inhibiting UGT2B17, alone or in combination with administration of testosterone, testosterone deficiency in men can be treatable. Further, a method of dose selection for precise dosing of UGT2B17 substrate drugs is provided. Additionally, methods for safe dosing of pharmaceutical agents that undergo UGT2B17-mediated acyl glucuronidation are provided.
