PROBLEM TO BE SOLVED: To provide new substances having a macrophage intrafat drop accumulation-inhibiting action and originated from a microorganism.SOLUTION: Provided is the method for producing new FKI-1746-1 and FKI-1746-2 substances, characterized by culturing a microorganism belonging to genus Aspergillus and having ability to produce the FKI-1746-1 and FKI-1746-2 substances, especially Aspergillus clavatonanicus FKI-1746 (FERM AP-21482), in a culture medium, and then collecting the FKI-1746-1 and/or FKI-1746-2 substances from the culture product. The new substances have a macrophage intrafat drop accumulation-inhibiting action, and are effective for preventing and treating arteriosclerosis and diseases caused by the arteriosclerosis.COPYRIGHT: (C)2009,JPO&INPIT【課題】微生物由来のマクロファージ内脂肪滴蓄積阻害作用を有する新規物質を提供する。【解決手段】アスペルギルス属に属し、化合物FKI-1746-1及び/又は化合物FKI-1746-2を生産する能力を有する微生物、特にアスペルギルス・クラバトナニクスFKI-1746(Aspergillus clavatonanicus FKI-1746)(FERM AP-21482)を培地に培養し、培養物からFKI-1746-1物質及び/又はFKI-1746-2物質を採取する。これらの新規物質はマクロファージ内脂肪滴蓄積阻害作用を有し、動脈硬化症やそれに起因する疾病の予防、治療に有効である。【選択図】なし
