ПРИСЯЖНОВ Виктор (DE),МАТТЕККА Штефан (DE),ШЕРИФФ Ахмед (DE),ЗЮССМУТ Родерих (DE)
申请号：
RU2017101500
公开号：
RU2017101500A
申请日:
2015.06.19
申请国别(地区):
RU
年份:
2018
代理人:
摘要：
The present invention provides phosphoryl choline derivatives of general formula (I), which are suitable to be immobilized on a solid support to provide a separation material, which bind with both high affinity and high specificity to a protein, more specifically to C-reactive protein and anti-phosphoryl choline antibodies. Said separation materials are particularly useful in the extracorporeal removal of C-reactive protein and anti-phosphoryl choline antibodies from a biological fluid of a patient for prophylaxis and/or treatment of immune dysfunctions and cardiovascular diseases. Also claimed is a device containing a column that comprises separation material made from formula (I) wherein L is a linker as defined in the claims； X is selected from: -SH, -NHR 3 , -C=CH, -CH=CH 2 , -N 3 , -CHO. Also claimed is a separation material of general formula (II): wherein A is a solid support； Y is a group obtainable from the reactive group X.
