Compounds for use in prevention and treatment of neurodegenerative disease and pain are disclosed. In one embodiment of the invention, the compound is selected from the group consisting ofN6-[(3-halothien-2-yl)methyl]adenosine,N6-[(4-halothien-2-yl)methyl]adenosine, andN6-[(5-halothien-2-yl)methyl]adenosine. In another embodiment of the invention, the compound is selected from the group consisting ofN6-[(2-bromothien-3-yl)methyl]adenosine,N6-[(4-bromothien-3-yl)methyl]adenosine,N6-[(5-bromothien-3-yl)methyl]adenosineN6-[(2-chlorothien-3-yl)methyl]adenosine,N6-[(4-chlorothien-3-yl)methyl]adenosine, andN6-[(5-chlorothien-3-yl)methyl]adenosine. Also disclosed are methods of making and using the same.本發明係揭示用於預防及治療神經退化疾病及疼痛之化合物。在本發明之一具體實施例中,化合物係選自於由N6-[(3-鹵噻吩-2-基)甲基]腺苷、N6-[(4-鹵噻吩-2-基)甲基]腺苷、及N6-[(5-鹵噻吩-2-基)甲基]腺苷組成之群組。在本發明之另一具體實施例中,化合物係選自於由N6-[(2-溴噻吩-3-基)甲基]腺苷、N6-[(4-溴噻吩-3-基)甲基]腺苷、N6-[(5-溴噻吩-3-基)甲基]腺苷、N6-[(2-氯噻吩-3-基)甲基]腺苷、N6-[(4-氯噻吩-3-基)甲基]腺苷、及N6-[(5-氯噻吩-3-基)甲基]腺苷組成之群組。本發明亦揭示其製造及使用之方法。
