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SUMOYLATION OF SERCA2A AND CARDIOVASCULAR DISEASE
专利权人:
发明人:
Roger Joseph Hajjar,Chang Won Kho,Ah Young Lee
申请号:
US15281269
公开号:
US20170014494A1
申请日:
2016.09.30
申请国别(地区):
US
年份:
2017
代理人:
摘要:
Methods for treating cardiovascular disease, and in particular heart failure, are provided comprising administering a therapeutically effective amount of a modulator of SERCA2a post-translation modification such as SUMOylation or acetylation. Also provided are methods of treating cardiovascular disease by inhibiting SERCA2a degradation. Further provided are methods of diagnosing a propensity to develop heart failure comprising determining if a SERCA2a mutant is present or determining the level of expression of SUMO1 in cardiomyocytes. The disclosure also provides methods of screening for therapeutics that modulate the post-translational modification of SERCA2a, such as by modulating post-translational SUMOylation and/or acetylation.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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