Systems for Fixation of Fractures of Long Bone and Methods Thereof. The present invention in a preferred embodiment involves a system for fixation of a long bone fracture using implantable devices, the system comprising of an intramedullary nail, and an interlocking screw or bolt, wherein the interlocking screw or bolt has a hole in its body for locking the intramedullary nail and also a method of using the system. In the system of the present invention, instead of a hole being present in the intramedullary nail, a hole is present in the body of the interlocking screw or bolt, wherein the intramedullary nail is made to pass through the hole of the interlocking screw or bolt and is made to fit into the hole.