A quick-release guide assembly (10) for an external fixation system comprises a device body (10, 13) with at least one hole (14) and a handle portion with a handle bar. The device body (10, 13, 20) comprises at least one appendage (11, 12) having a first connecting portion (20). The handle comprises a complementary second connecting portion, wherein one connecting portion comprising a spring actuated locking pin, wherein an actuator knob is provided to release the locking pin. Therefore the connecting portions of the handle can be releasably attached to the device body (10, 13, 20), enabling a quick change of device bodies (13) having different oriented and arranged holes (14).