The present invention provides a compound of formula (I) in free form or in pharmaceutically acceptable salt form a method for manufacturing the compound of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and pharmaceutical compositions.本發明提供一種式(I)化合物,呈自由形式或醫藥學上可接受之鹽形式,一種製造本發明化合物之方法,及其治療用途。本發明進一步提供藥理學活性劑之組合及醫藥組合物。