This Hair is bright to provide formula (I) compound of Ke Jie Shou Which form on Cheng You From form Huo Drug Learn, the method for the bright compound of Yong Yu this Hair of System Prepare and its controls Treatment purposes. Mono- step of this Hair Ming Jin provides Drug reason activity Elixirs Group and closes and Drug Wu Group conjunction object.本發明提供呈游離形式或藥學上可接受鹽形式的式(I)化合物,用於製備本發明化合物的方法及其治療用途。本發明進一步提供藥理活性劑的組合和藥物組合物。