The invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; a method for preparing the compound of the invention and its therapeutic use. The invention also provides a combination of pharmacological active agents and pharmaceutical compositions.本發明提供了式(I)化合物或其藥學上可接受的鹽;製備本發明化合物的方法和其治療用途。本發明還提供藥理學活性劑的組合和藥物組合物。