A PROCESS FOR PRODUCING LERCANIDIPINE HC1 FORM V

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专利权人:

发明人:

AMEDEO LEONARDI,GIANNI MOTTA,LUC JACQUET

申请号：

IN9292/DELNP/2010

公开号：

IN2010DN09292A

申请日:

2010.12.28

申请国别(地区):

IN

年份:

2012

代理人:

摘要：

The present invention relates to a new process for obtaining crystalline Lercanidipine.HCl Form V. The process includes (i) crystallization from a mixture of iPrOAc and an aprotic polar organic solvent, such as ACN, Me2CO, DMF or DMA or (ii) slurrying Lercanidipine.HCl in iPrOAc. More in details, crystalline Lercanidipine.HCl, preferably Form I, is normally dissolved in DMF or DMA whereas amorphous Lercanidipine.HCl is normally dissolved in ACN or acetone. When Lercanidipine.HCl is slurried in iPrOAc, this is preferably done using amorphous Lercanidipine.HCl.

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