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Morphinan derivative
专利权人:
Hiroshi Nagase
发明人:
Hiroshi Nagase,Hideaki Fujii,Eriko Nakata,Yoshikazu Watanabe,Toshihiro Takahashi
申请号:
US14343218
公开号:
US08952030B2
申请日:
2012.09.07
申请国别(地区):
US
年份:
2015
代理人:
摘要:
A morphinan derivative represented by the following general formula (I):(in the formula, R1 represents hydrogen, C1-6 alkyl, cycloalkylalkyl (the cycloalkyl moiety has 3 to 6 carbon atoms, and the alkylene moiety has 1 to 5 carbon atoms), aralkyl (the aryl moiety has 6 to 10 carbon atoms, and the alkylene moiety has 1 to 5 carbon atoms) and the like, R2 represents hydrogen, C1-6 alkyl, C3-6 cycloalkyl, C6-10 aryl, aralkyl (the aryl moiety has 6 to 10 carbon atoms, and the alkylene moiety has 1 to 5 carbon atoms) and the like, R3, R4 and R5 represent hydrogen, hydroxy, carbamoyl, C1-6 alkoxy, C6-10 aryloxy and the like, R6a, R6b, R7, R8, R9, and R10 represent hydrogen and the like, X represents O or CH2, and Y represents C═O, SO2, an atomic bond and the like), or an acid addition salt thereof is used as an analgesic.
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