MCCARRON ASHLEY SUE,SELLS TODD B,STIRLING MATTHEW,STROUD STEPHEN G
申请号：
TN2014000080
公开号：
TN2014000080A1
申请日:
2014.02.21
申请国别(地区):
TN
年份:
2015
代理人:
摘要：
Disclosed are chemical entities which are inhibitors of Nedd8-activating enzyme (NAE), namely, the compound {(1S,2S,4R)-4-[(6-{[(1R,2S)-5-chloro-2-methoxy-2,3-dihydro-1H-inden-1-yl]amino}pyrimidin-4-yl)oxy]-2-hydroxycyciopentyl}methyl sulfamate and pharmaceutically acceptable salts thereof； solid state forms thereof； and prodrugs thereof. Also disclosed are methods of using the chemical entities to treat disorders such as cancer.
