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Inhibitors of NEDD8-activating enzyme
专利权人:
Inc.;Millennium Pharmaceuticals
发明人:
Ashley Sue McCarron,Todd B. Sells,Matthew Stirling,Stephen G. Stroud
申请号:
US14326051
公开号:
US09850214B2
申请日:
2014.07.08
申请国别(地区):
US
年份:
2017
代理人:
摘要:
Disclosed are chemical entities which are inhibitors of Nedd8-activating enzyme (NAE), namely, the compound {(1S,2S,4R)-4-[(6-{[(1R,2S)-5-chloro-2-methoxy-2,3-dihydro-1H-inden-1-yl]amino}pyrimidin-4-yl)oxy]-2-hydroxycyclopentyl}methyl sulfamate and pharmaceutically acceptable salts thereof; solid state forms thereof; and prodrugs thereof. Also disclosed are methods of using the chemical entities to treat disorders such as cancer.
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中国工程科技知识中心
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