Ashley Sue McCarron,Todd B. Sells,Matthew Stirling,Stephen G. Stroud
申请号：
US14326051
公开号：
US09850214B2
申请日:
2014.07.08
申请国别(地区):
US
年份:
2017
代理人:
摘要：
Disclosed are chemical entities which are inhibitors of Nedd8-activating enzyme (NAE), namely, the compound {(1S,2S,4R)-4-[(6-{[(1R,2S)-5-chloro-2-methoxy-2,3-dihydro-1H-inden-1-yl]amino}pyrimidin-4-yl)oxy]-2-hydroxycyclopentyl}methyl sulfamate and pharmaceutically acceptable salts thereof； solid state forms thereof； and prodrugs thereof. Also disclosed are methods of using the chemical entities to treat disorders such as cancer.
