D&APOSAGOSTINO, LAURA AKULLIAN,SJIN, ROBERT TJIN THAM,NIU, DEQIANG,MCDONALD, JOSEPH JOHN,ZHU, ZHENDONG,LIU, HAIBO,MAZDIYASNI, HORMOZ,PETTER, RUSSELL C.,SINGH, JUSWINDER,BARRAGUE, MATTHIEU,GROSS, ALEXA
申请号：
PE0020222015
公开号：
PE17762015A1
申请日:
2014.03.14
申请国别(地区):
PE
年份:
2015
代理人:
摘要：
Relates to compounds of formula I or a pharmaceutically acceptable salts of the same, in which X1 is NH, N or CH, CH2, among others x2 is NH, N or CH, CH2, among others X3 and X4 are independently N or CH, among others X5 is n or CH, C where At least one of X1, X2, X3, X4 or X5 is n g H, o, oh or NH2, among others is optionally substituted phenyl,A Ring carbociclico C3 - 8 or an optionally substituted Heterocyclic Ring of 4 - 7 - 1 4 Member containing heteroatom (o, N or S) optionally replaced, among others and R1 is - L, where l is a Chain of Bivalent Hydrocarbon C2 - 8, among others, e and H, halogen NO2 or CN, among others ca Whatever gives R2 is H, halogen, Oh, sh, CN, NO2, so2h (C, h, o) C (o) C (o) NH2, Oh, NH2,Among others R3 is absent or is H, alkyl alquenilo C2 or C1 - 6 - 6, among others and it is o or NH, among others t is a Covalent Bond or a divalent Hydrocarbon Chain of C1 - 6, among others and q is 0 - 6.These compounds are inhibitors of one or several Protein Kinases (in particular fgfr4) that contain a cysteine residue in the ATP binding site, which are useful in the therapy of a variety of diseases, Disorders or conditions asicoadas with cellular responses to abnormal Sencadenadas Events mediated by Protein Kinases.Particularly to prevent the growth or induce apoptosis of tumors, in particular by inhibiting angiogenesisSE REFIERE A COMPUESTOS DE FORMULA I O SALES FARMACEUTICAMENTE ACEPTABLES DE LOS MISMOS, EN LOS CUALES X1 ES NH, N, CH2 o CH, ENTRE OTROS X2 ES NH, N, CH2 o CH, ENTRE OTROS X3 Y X4 SON INDEPENDIENTEMENTE N o CH, ENTRE OTROS X5 ES N, C o CH EN DONDE AL MENOS UNO DE X1, X2, X3, X4 o X5 ES N G ES H, O, OH o NH2, ENTRE OTROS A ES FENILO OPCIONALMENTE SUSTITUIDO, UN ANILLO CARBOCICLICO C3-8 OPCIONALMENTE SUSTITUIDO, O UN ANILLO HETEROCICLICO DE 4-7 MIEMBROS CONTENIENDO 1-4 HETEROATOMOS (O, N o S) OPCIONALMENTE SUSTITUIDO, ENTRE OTROS R1 ES -L-Y, DONDE L ES UNA CADENA DE HIDROCARBURO C2-8 BIVALENTE, ENTRE OTROS, E Y ES H, HALOGENO, NO2 O C
