PEPTIDES PORTEURS DU MANNOSE-6-PHOSPHATE FUSIONNES AVEC DES ENZYMES LYSOSOMIALES

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专利权人:

INC.;SHIRE HUMAN GENETIC THERAPIES

发明人:

CONCINO, MICHAEL F.,STRACK-LOGUE, BETTINA,MEIYAPPAN, MUTHURAMAN,NORTON, ANGELA W.,ZHANG, BOHONG,ISKENDERIAN, ANDREA,LOW, LIEH YOON,LUNDBERG, DIANNA,ROMASHKO, ALLA,NAIMY, HICHAM

申请号：

CA2956469

公开号：

CA2956469A1

申请日:

2015.08.11

申请国别(地区):

CA

年份:

2016

代理人:

摘要：

A targeted therapeutic including a lysosomal enzyme and a lysosomal targeting moiety that is a peptide containing at least one N-linked glycosylation site. Methods of producing the targeted therapeutic may include nucleotide acids encoding the same and host cells co-expresing GNPT. Pharmaceutical compositions comprising the targeted therapeutic and methods of using the same to treat a lysosomal storage disease.

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