Mannose-6-phosphate bearing peptides fused to lysosomal enzymes

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专利权人:

Inc.;Shire Human Genetic Therapies

发明人:

Concino, Michael F.,Strack-Logue, Bettina,Meiyappan, Muthuraman,Norton, Angela W.,Zhang, Bohong,Iskenderian, Andrea,Low, Lieh Yoon,Lundberg, Dianna,Romashko, Alla,Naimy, Hicham

申请号：

AU2015301809

公开号：

AU2015301809A1

申请日:

2015.08.11

申请国别(地区):

AU

年份:

2017

代理人:

摘要：

A targeted therapeutic including a lysosomal enzyme and a lysosomal targeting moiety that is a peptide containing at least one N-linked glycosylation site. Methods of producing the targeted therapeutic may include nucleotide acids encoding the same and host cells co-expresing GNPT. Pharmaceutical compositions comprising the targeted therapeutic and methods of using the same to treat a lysosomal storage disease.

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中国工程科技知识中心

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