The present invention relates to complexes of the LYST or LYST-2 protein wit h proteins identified as interacting with LYST or LYST-2 by a modified yeast t wo hybrid assay system. The proteins identified to interact with LYST or LYST-2 are 14-3-3 protein, HS1 protein, Hrs, BMK1, KB07, Efs, XAP-4, OS9, casein kinase II beta SU, calmodulin, troponin I, importin beta, Fte-1, hERR1, imog en 38, atrophin-1, norbin, HBF-G2, DGS-I, GBDR1, OPA containing protein, M4 protein, LIP1, LIP2, LIP3, LIP4, LIP5, LIP6, LIP7, LIP8, LIP9 and LIP10. Thu s, the invention provides complexes of LYST or LYST-2 and 14-3-3 protein, HS1 protein, Hrs, BMK1, KB07, Efs, XAP-4, OS9, casein kinase II beta SU, calmodulin, troponin I, importin beta, Fte-1, hERR1, imogen 38, atrophin-1, norbin, HBF-G2, DGS-I, GBDR1, OPA containing protein, M4 protein, LIP1, LIP2 , LIP3, LIP4, LIP5, LIP6, LIP7, LIP8, LIP9 and LIP10, and derivatives, fragmen ts and analogs thereof. The invention also provides nucleic acis encoding the LIP1, LIP2, LIP3, LIP4, LI
