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AZETIDINE DERIVATIVES, THEIR PREPARATION AND THEIR APPLICATION IN THERAPY
专利权人:
发明人:
申请号:
HK11106128.9
公开号:
HK1152038A
申请日:
2011.06.15
申请国别(地区):
HK
年份:
2012
代理人:
摘要:
The present invention provides the compounds conforming to the formula (I) in which: R represents a (C1-C6)alkyl or halo(C1-C6)alkyl group R represents a group NR4R5 or OR8 A and B, when present, represent independently of one another, one or two carbon atoms, these carbon atoms being substituted by one or more hydrogens or (C1-C6)alkyl groups the (C1-C6)alkyl group or groups being optionally substituted A+B represent two carbons at most R1 represents a hydrogen atom or a (C1‑C6)alkyl group R2 and R3 represent, independently of one another, a hydrogen atom or a (C1-C6)alkyl group the (C1-C6)alkyl group being optionally substituted R4 and R5 represent, independently of one another, a hydrogen atom or a (C1-C6)alkyl group, or form, with the nitrogen atom which carries them, a heterocycle of the azetidine, pyrrolidine, piperidine, azepan, piperazine, homopiperazine, morpholine, thiomorpholine, thiomorpholine S-oxide or thiomorpholine S-dioxide type, this heterocycle being optionally substituted by a (C1-C6)alkyl group R6 and R7 each represent a phenyl group, which is optionally substituted Y represents a hydrogen atom, a halogen or a (C1-C6)alkyl group, halo(C1‑C6)alkyl, (C1-C6)alkoxy, halo(C1-C6)alkoxy, (C1-C6)alkylS(O)p or cyano group R8 is a hydrogen atom, a (C1-C6)alkyl group, a halo(C1‑C6)alkyl group, an allyl group or a phenyl(C1-C6)alkyl group, the phenyl group being optionally substituted by 1 or 2 O-methyl groups p represents an integer selected from 0, 1 and 2 in the form of the base  or an addition salt with an acid or with a base. Preparation process and application in therapy.La présente invention a pour objet les composés répondant à la formule (I) dans laquelle : R représente un groupe (C1-C6)alkyle, halo(C1-C6)alkyle R représente un groupe NR4R5, OR8 A et B, sils sont présents, représentent indépendamment lun de lautre, un ou deux atomes de carbone, ces atomes de carbones étant substitués par un ou plusieurs hydrogènes, groupes (C1-C6)alkyle le ou les g
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