The present invention relates to a novel process for obtaining a modafinil-based pharmaceutical composition. This process consists in solubilizing S-modafinil in a fluid in the supercritical state, and then, after reducing the pressure of said fluid, in recovering said S-modafinil by absorbing it at the surface of a substrate which is in the form of granules. Said fluid may be CO2 or another solvent and the substrate may be anhydrous lactose or mannitol. Use of the pharmaceutical composition in cases where increased vigilance in the short term and over a brief period of time is required in the person taking said pharmaceutical composition.
