Process for obtaining a modafinil-based pharmaceutical composition, resulting pharmaceutical composition and use thereof

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专利权人:

DEBREGEAS ET ASSOCIES PHARMA

发明人:

LEBON CHRISTOPHE,SUPLIE PASCAL,LEBOEUF FABRICE,JUNG JENNIFER,DESCHAMPS FRANTZ

申请号：

NZ62800713

公开号：

NZ628007A

申请日:

2013.02.25

申请国别(地区):

NZ

年份:

2015

代理人:

摘要：

Disclosed is a process for obtaining S-modafinil (2-[(diphenylmethyl)sulfinyl)] acetamide) pharmaceutical compositions (levorotatory from) comprising: solubilising S-modafinil in a fluid in the supercritical state (e.g., CO2, tetrafluoroethane)； reducing the pressure of the fluid； and recovering S-modafinil by absorbing it at the surface of an inert support (e.g., mannitol, anhydrous lactose) in the form of granules. The process results in S-modafinil with increased solubility and bioavailability.

来源网站：

中国工程科技知识中心

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http://www.ckcest.cn/home/