Refers to a compound derived from 2-oxo-1-pyrrolidinyl imidazotiadiazol formula (i) wherein: R1 is c1-4 alkyl Substituent containing at least a Halogen such as 2,2 - difluoropropilo, 2 - chlorine - 2.2 - difluoroetilo, among others R2 is c1-4 alkyl or Halogen containing at least a replaced Between Halogen such as chlorine, difluorometilo,Among others R3 is c1-4 alkyl containing at least one Hydroxy or alkoxy Substituent such as hydroxymethyl, metoximetilo, among others.Preferred compounds are: 4 - (2,2 - difluoropropil) - 1 - [2 - (methoxymethyl) - 6 - (trifluoromethyl) imidazo [2,1-b] - 5 - [1,3,4] thiadiazole il] methyl} pyrrolidin-2-one (4S) - 4 - (2 - chlorine - 2.2 - difluoroetil) - 1 - [2 - (hydroxymethyl) - 6 - (trifluoromethyl) imidazo [2,1-b] - 5 - [1,3,4] thiadiazole il] methyl} pyrrolidin-2-one 1 - {[2 - (6 - Chloro - met Oxymethyl) imidazo [2,1-b] [1,3,4 thiadiazole il]] - 5 - methyl - 4 - (3,3},3 - trifluoropropil) pyrrolidin-2-one among others. It also relates to a Pharmaceutical Composition and a preparation method. This Compound is useful for the treatment of Seizure Disorders, Epilepsy, seizures RefractorySE REFIERE A UN COMPUESTO DERIVADO DE 2-OXO-1-PIRROLIDINIL IMIDAZOTIADIAZOL DE FORMULA (I) DONDE: R1 ES ALQUILO C1-4 QUE CONTIENE AL MENOS UN SUSTITUYENTE HALOGENO TALES COMO 2,2-DIFLUOROPROPILO, 2-CLORO-2,2-DIFLUOROETILO, ENTRE OTROS R2 ES HALOGENO O ALQUILO C1-4 QUE CONTIENE AL MENOS UN SUSTITUYENTE HALOGENO TALES COMO CLORO, DIFLUOROMETILO, ENTRE OTROS R3 ES ALQUILO C1-4 QUE CONTIENE AL MENOS UN SUSTITUYENTE HIDROXI O ALCOXI TALES COMO HIDROXIMETILO, METOXIMETILO, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: 4-(2,2-DIFLUOROPROPIL)-1-{[2-(METOXIMETIL)-6-(TRIFLUOROMETIL)IMIDAZO[2,1-b][1,3,4]TIADIAZOL-5-IL]METIL}PIRROLIDIN-2-ONA (4S)-4-(2-CLORO-2,2-DIFLUOROETIL)-1-{[2-(HIDROXIMETIL)-6-(TRIFLUOROMETIL)IMIDAZO[2,1-b][1,3,4]TIADIAZOL-5-IL]METIL}PIRROLIDIN-2-ONA 1-{[6-CLORO-2-(METOXIMETIL)IMIDAZO[2,1-b][1,3,4]TIADIAZOL-5-IL]METIL}-4-(3,3,3-TRIFLUOROPROPIL)P
