Nemunaitis, John J.,Senzer, Neil,Maples, Phillip B.,Rao, Donald
申请号：
AU2010333753
公开号：
AU2010333753A1
申请日:
2010.12.20
申请国别(地区):
AU
年份:
2012
代理人:
摘要：
The present invention includes compositions and methods for cancer treatment. More specifically the present invention describes an autologous cancer vaccine genetically modified for Furin knockdown and GM-CSF expression. The vaccine described herein attenuates the immunosuppressive activity of TGF-β through the use of bi-functional shRNAs to knock down the expression of furin in cancer cells, and to augment tumor antigen expression, presentation, and processing through expression of the GM-CSF transgene.
