Neil Senzer;Donald Rao;Phillip B. Maples;John J. Nemunaitis
发明人:
John J. Nemunaitis,Neil Senzer,Phillip B. Maples,Donald Rao
申请号：
US12973823
公开号：
US09132146B2
申请日:
2010.12.20
申请国别(地区):
US
年份:
2015
代理人:
摘要：
Compositions and methods for cancer treatment are discloses herein. More specifically the present invention describes an autologous cancer vaccine genetically modified for Furin knockdown and GM-CSF expression. The vaccine described herein attenuates the immunosuppressive activity of TGF-β through the use of bi-functional shRNAs to knock down the expression of furin in cancer cells, and to augment tumor antigen expression, presentation, and processing through expression of the GM-CSF transgene.
