John J. Nemunaitis,Neil Senzer,Phillip B. Maples,Donald Rao
申请号：
US14815721
公开号：
US20150329873A1
申请日:
2015.07.31
申请国别(地区):
US
年份:
2015
代理人:
摘要：
Compositions and methods for cancer treatment are disclosed herein. More specifically the present invention describes an autologous cancer vaccine genetically modified for Furin knockdown and GM-CSF expression. The vaccine described herein attenuates the immunosuppressive activity of TGF-β through the use of bi-functional shRNAs to knock down the expression of furin in cancer cells, and to augment tumor antigen expression, presentation, and processing through expression of the GM-CSF transgene.
