The invention provides a composition for slowing down the side effects of chemotherapy drugs, the composition comprises a soybean fermentation liquid, which is produced by CO culturing a soybean liquid and a microbial probiotic group, wherein the microbial probiotic group is composed of the microorganisms of Bifidobacterium, bacillus, Lactobacillus, Lactococcus and Streptococcus, and the composition is characterized by Cisplatin is the therapeutic drug.The invention can effectively improve the side effects of liver and kidney function damage, white blood cell and hemoglobin number reduction, food consumption reduction and weight loss caused by cisplatin.本發明提供一種減緩化療藥物副作用之組合物,該組合物含有一大豆發酵液,該大豆發酵液係將一大豆液與一微生物益生菌群共同培養而製得,其中該微生物益生菌群係由雙歧桿菌屬、芽孢桿菌屬、乳桿菌屬、乳酸球菌屬及鏈球菌屬之微生物所組成的群組,且該化療藥物係為順鉑(Cisplatin)。本發明有效改善化療藥物順鉑引起的肝腎功能損傷、白血球與血紅蛋白數目減少、食量減少及體重減輕之副作用。