Core containing the active ingredient (a) biological, an osmotic formulation comprising at least one passageway through (c) the semi-permeable membrane and the semi-permeable membrane covering (b) the core The semipermeable membrane comprises a water-soluble plasticizer and methacrylic polymers ethyl cellulose, acrylic, and the semi-permeable membrane the semipermeable except the water-soluble plasticizer, optionally free or water-soluble substances based on the total dry weight of the membrane, including 15% by weight or less.(a)生物学的に活性な成分を含むコア、(b)前記コアを覆う半透過性膜及び(c)前記半透過性膜を通る少なくとも1つの通路を含んでなる浸透性製剤であって、前記半透過性膜がエチルセルロース、アクリル又はメタクリルポリマー及び水溶性可塑剤を含むが、前記半透過性膜は任意の水溶性可塑剤を除き、水溶性物質を含まないか、又は前記半透過性膜の総乾燥重量に基づき、15重量%以下含む。
