Giuseppe Claudio Viscomi,Laura Chelazzi,Fabrizia Grepioni,Dario Braga,Maddalena Kindt
申请号：
US13935331
公开号：
US09452157B2
申请日:
2013.07.03
申请国别(地区):
US
年份:
2016
代理人:
摘要：
The present invention relates to rifaximin compositions comprising amino acids, characterized in that they increase rifaximin solubility in aqueous solutions and are useful in the treatment of disease wherein amino acids and rifaximin are efficacious. The present invention also relates to pharmaceutical compositions comprising rifaximin or one of the pharmaceutically acceptable salts thereof and one or more amino acid(s), wherein the molar ratio between the amino acid(s) and rifaximin is from 1:1 to 10:1, together with pharmaceutically acceptable excipients. The present invention further relates to rifaximin crystals obtained by dissolving rifaximin and amino acids in solutions formed by ethanol/water and evaporating the solution.
