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Process for the preparation of bioadhesive compact matrices
专利权人:
UNIVERSITA' DEGLI STUDI DI GENOVA
发明人:
CAVIGLIOLI, GABRIELE,PARODI, BRUNELLA,RUSSO, ELEONORA,CAFAGGI, SERGIO,BIGNARDI, GAETANO,CIRRINCIONE, PAOLA
申请号:
DK09778448
公开号:
DK2344140T3
申请日:
2009.09.10
申请国别(地区):
DK
年份:
2014
代理人:
摘要:
A method for the preparation of a bioadhesive compact matrix, which comprises the preparation of a uniform mixture of powders comprising one alkylcellulose or one hydroxyalkylcellulose and a non-water-soluble, water-swellable cross-linked polycarboxylic polymer; the preparation of compressed units starting from such powder mixture by direct compression and finally the heating of the compressed units thus obtained to a temperature in the range of 80 - 250°C for a time of 1-60 minutes; the powder mixture can also comprise at least one active substance and the compressed units thus obtained are characterized by a prolonged release, and have a release kinetics of the active substance substantially of zero order in an aqueous solution at pH 4-8.
来源网站:
中国工程科技知识中心
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