CHEN, CHIH CHENG,陈志成,陳志成,LIN, YUN LIAN,林云莲,林雲蓮,FANG, JIM MIN,方俊民,CHERN, YIJUANG,陈仪庄,陳儀莊,LIN, CHIA CHING JOHN,林家靖,CHEN, WEI NAN,陈威男,陳威男,LIN, CHUN JUNG,林君荣,林君榮
申请号：
TW102105627
公开号：
TWI494111B
申请日:
2013.02.18
申请国别(地区):
TW
年份:
2015
代理人:
摘要：
The invention provides a new use of adenosine analogs for the treatment of pain through activation of neurokinin 1 (NK1) receptor signaling pathway, thereby inducing the activation of activation of M-type potassium channel to induce outward currents. A method and pharmaceutical composition for treating pain comprising an adenonsine analog that activates NK1 receptor signaling, thereby inducing outward current are also provided.本發明係提供一種腺苷類似物於治療疼痛之新用途，其係透過活化神經激肽1(NK1)受體訊息傳導途徑，藉以誘發活化M-型鉀離子通道之活化作用，以誘發外向電流。本發明亦提供一種治療疼痛之方法及醫藥組成物，其包含可活化NK1受體訊息傳導之腺苷類似物，藉以誘發外向電流。
