PROBLEM TO BE SOLVED: To provide a novel skin-beautifying method and an evaluation method of a substance exhibiting a skin-beautifying effect.SOLUTION: The skin-beautifying method includes inhibiting activities of heparanase existing in the skin. The evaluation method of a skin-beautifying effect of a subject substance includes bringing the subject substance into contact with a skin, a skin tissue or a skin cell of a human or an animal, measuring enzyme activities of heparanase in the skin and evaluating skin-beautifying effects of the subject substance using as an index the changes in the enzyme activities of heparanase.COPYRIGHT: (C)2011,JPO&INPIT【課題】新規美白方法及び美白効果を有する物質の評価方法の提供。【解決手段】本発明は、皮膚に存在するヘパラナーゼの活性を抑制することを特徴とする、美白方法、並びにヒトまたは動物の皮膚、皮膚組織または細胞に被験物質を接触させ、前記皮膚におけるヘパラナーゼの酵素活性を測定し、ヘパラナーゼの酵素活性の変化を指標として被験物質の美白効果を評価することを特徴とする、被験物質の美白効果の評価方法を提供する。【選択図】図1
