BROWN, Patricia A.,WEINER, David B.,FERRARO, Bernadette,YAN, Jian,BOWLING, Rodney A.,KERN, Douglas, R.,RAMANATHAN, Mathura P.,SARDESAI, Niranjan Y.
申请号：
AU2014271312
公开号：
AU2014271312A1
申请日:
2014.12.04
申请国别(地区):
AU
年份:
2015
代理人:
摘要：
#$%^&*AU2014271312A120150115.pdf#####EDITORIAL NOTE 2014271312 - The Abstract includes what appears to be a drawing/flow chart which also is presented on the Abstracts for the divisional parentABSTRACT Provided herein is a nucleic acid comprising consensus amino acid sequence of foot-andmouth disease FMDV VP1-4 coat proteins of FMDV substypes A, Asia 1, C, 0, SAT1, SAT2, and SAT3 as well as plasmids and vaccines expressing the sequences. Also provided herein is methods for generating an immune response against one or more FMDV subtypes using the vaccine as described above as well as methods for deciphering between vaccinated mammals with the vaccine and those that are infected with FMDV. FM-V1--C.(si1 Consensus Consensus Consensus Consensus Consensus 2916-bp )VP1 (Asia 1) VP2 (Asia 1) VP3 (Asia 1) VP4 (Asia 1) 3 (Asia 1) 2916 bp ....... Consensus Consensus Consensus Cosnu osnsus FMD-VP1 -4-C3 (A) VP1 (A) VP2 A) VP3 A VP4 A 03 (A FMD-VP1-4-3 (0) VP1 (0) VP2 (0) VP3 (0) VP4 (0) C3 () 2913 bp tA Co nsens us Co nsens us Co nsens us Co nsens us Conse ns us FMD-VP1-4-C3 (0) -VP1 VP2 0 VP3 0 VP4 0 03 0 FMD-VP1-4-C3 (SAT) ~ gE VP1 (SAT) VP2 (SAT) VP3 (SAT) VP4 (SAT) C3 SAT1) 292 bp........ Consensus Consensus Consensus Consensus Consensus. FMD-VP1-4-3 (SAT2) VP1 (SAT2) VP2 (SAT2) VP3 (SAT2) VP4 (SAT2) C3 SAT2 Consensus Consensus Consensus Consensus Consensus FM-P14C3(AT) - VP 1 (SAT3) VP2 (SAT3) VP3 (SAT3) VP4 (SAT3) C32 (SAT3) 2940 bp FIVD-\P -03 (SAT3) 1 VE P $START o STOP * 03 cleavage site 48
