The Trustees of the University of Pennsylvania;Inovio Pharmaceuticals, Inc.
发明人:
Weiner, David B.,Ferraro, Bernadette,Yan, Jian,Brown, Patricia A.,Bowling, Rodney A.,Kern, Douglas R.,Ramanathan, Mathura P.,Sardesai, Niranjan Y.,Muthumani, Karuppiah
申请号：
AU2018201443
公开号：
AU2018201443A1
申请日:
2018.02.28
申请国别(地区):
AU
年份:
2018
代理人:
摘要：
#$%^&*AU2018201443A120180329.pdf#####ABSTRACT Provided herein is a nucleic acid comprising consensus amino acid sequence of foot-andmouth disease FMDV VP 1-4 coat proteins of FMDV substypes A, Asia 1, C, 0, SAT 1, SAT2, and SAT3 as well as plasmids and vaccines expressing the sequences. Also provided herein is methods for generating an immune response against one or more FMDV subtypes using the vaccine as described above as well as methods for deciphering between vaccinated mammals with the vaccine and those that are infected with FMDV. FMD-VP 1-4-C3 (Asia 1) IgE cosesu Consensusf Coonsensu nsnu onesus 29D-VP164-C3 (Asia 1) IgE VP1 (Asia 1 VP2 (Asia 1 VP3 (Asia 1) VP4 Asia 1 3 Asia 1 2916 bp M P Ai )C Ai s FMD-VP1-4-C3 (A) IgE Cos A Vos A VP3 A V4 A c 2916 bp 0 A Consensus Consensus Consensus Consensus Consensus. FMD-VP1-4-C3 (C) IgE VP1 C VP2 C VP3 C VP4 C C3 C FMD-VP 1-4-C3 (O) IgE Consensus Consensus Consensus onsensus " osnu 2925 bp VP1 (0) VP2 (0) VP3 (0) VP4 (0) C3 (0) Consensus Consensus Consensus Consensus Consensus FMD-VP1-4-C3 (SATi) IgE VP AiVP2 (SATi VP3 (SAT-I VP4 SATi 3S1 2952 bp FMD-VP1-4-C3 (SAT2) IgE VP1 (SAT2) VP2 (SAT2) VP3 (SAT2) VP4 (SAT2) C3 SAT2) 2940 bp # ffffV4(suIl FMD-VP1-4-C3 (SAT3) IgE SAT3 VP2 SAT3 VP3 SAT3 VP4 SAT3 0C3 SAT3 s 2938 bp START STOP C3 cleavage site
