SANDLER JAN KURT WALTER,BELLIN INGO,DJURIC DEJAN,KOLTER KARL,RUCKD SCHEL HOLGER
申请号：
IN10440/CHENP/2012
公开号：
IN2012CN10440A
申请日:
2012.12.14
申请国别(地区):
IN
年份:
2014
代理人:
摘要：
The invention relates to a method for producing nanoporous foamed active ingredient containing preparations in which the active ingredient is present embedded in a pharmaceutically acceptable polymer characterized in that in stage a) a polymeric molding compound or a polymer melt is loaded with an expanding agent at a pressure and a temperature at which the expanding agent is in the supercritical state in stage b) a temperature of the loaded polymeric molding compound or melt is controlled to a temperature which is in the range from 40 to +60�C preferably from 20 to +55�C and still more preferably from 0 to +50�C around the glass transition temperature of the unloaded polymeric molding compound and in stage c) the polymeric molding compound or melt which has been loaded in stage a) and the temperature of which has been controlled under pressure in stage b) is depressurized at a depressurization rate in the range from 15 000 to 200 000 MPa/sec.
