CARBOXYLIC ACID URAT1 INHIBITOR CONTAINING DIARYLMETHANE STRUCTURE, PREPARATION METHOD AND USE THEREOF

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专利权人:

LTD.;TIANJIN INSTITUTE OF PHARMACEUTICAL RESEARCH CO.

发明人:

GUILONG ZHAO,WEI LIU,QIAN SHANG,ZHIXING ZHOU,YULI WANG,YUQUAN LI,HAIZHI ZHANG,CHUAN LI,CHANGYING LIU,YUQIANG LIU,YAFEI XIE,JINGWEI WU,HUIHUI CHEN,WEIREN XU,LIDA TANG

申请号：

US15570151

公开号：

US20180134670A1

申请日:

2016.04.28

申请国别(地区):

US

年份:

2018

代理人:

摘要：

The present invention relates to the pharmaceutical field for the treatment of hyperuricemia and gout. In particular, the present invention relates to a carboxylic acid urate transporter 1 (URAT1) inhibitor of a general formula (I) containing a diarylmethane structure and a preparation method thereof, and a pharmaceutical composition containing the same and a use thereof in the preparation of medicaments for treating hyperuricemia and gout,wherein R1 is selected from H, C1-C10 alkyl, C3-C10 cycloalkyl, F, Cl, Br, I, CN, NO2, SR4 or OR4； R2 is selected from H, F, Cl, Br or I； R3 is selected from H or C1-C4 alkyl； X is selected from S or CH2； wherein R4 is selected from C1-C10 alkyl.

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