Surface modification method and structure for improving hemo-compatibility of biomedical metallic substrate capable of ensuring that the biomedical metallic substrate is non-toxic to the endothelial cells
The present invention relates to a surface modification method for improving hemo-compatibility of biomedical metallic substrate, which comprises: fixing a sulfur-containing monomolecular film on the surface of an oxide layer of a biomedical metallic substrate by means of molecular self-assembly. The surface modification substantially improves the hydrophilicity and hemo-compatibility of the biomedical metallic substrate that comes into touch with the blood, and ensures that the biomedical metallic substrate is non-toxic to the endothelial cells.一種增進生醫金屬基材血液相容性之表面修飾方法,包括:於一表面具有氧化層之生醫金屬基材通過分子自組裝之手段於該氧化層之表面固定含硫之單分子膜。本發明具體的增進了與血液接觸之生醫金屬基材之親水性、血液相容性,並確保對血管內皮細胞無毒性。
