genetically modified monoclonal antibodies and different from those found in nature, or antigen-binding portion thereof, therapeutic uses thereof, compositions, immunoconjugate, bispecific molecule comprising them, nucleic acid molecule and expression vector
E. R. SQUIBB & SONS, L.L.C.;MEDAREX, L.L.C.;ONO PHARMACEUTICAL CO., LTD.;MEDAREX, INC.
发明人:
Alan J. Korman,Bing Chen,Changyu Wang,Josephine M. Cardarelli,Mark J. Selby,Mohan Srinivasan
申请号：
BRPI0610235
公开号：
BRPI0610235B1
申请日:
2006.05.02
申请国别(地区):
BR
年份:
2020
代理人:
摘要：
the present invention provides genetically modified monoclonal antibodies and different from those found in nature, particularly human monoclonal antibodies that specifically bind to pd-1 with high affinity. nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. the invention also provides methods for detecting pd-1, as well as methods for treating various diseases, including cancer and infectious diseases, using anti-pd-1 antibodies. the present invention also provides methods for employing a combination immunotherapy, such as the combination of anti-beta-4 antibodies and anti-pd-1 antibodies, for treating hyperproliferative disease, such as cancer. the invention also provides methods for altering adverse events related to individual treatment with such antibodies. moreover, the invention discloses uses of anti-pd-1 antibodies alone or in combination with other immunotherapeutics for preparing pharmaceutical compositions for treating cancer.a presente invenção provê anticorpos monoclonais geneticamente modificados e diferentes daqueles encontrados na natureza, particularmente anticorpos monoclonais humanos que se ligam especificamente ao pd-1 com afinidade alta. são também providas moléculas de ácido nucléico codificando os anticorpos da invenção, vetores de expressão, células hospedeiras e métodos para expressão dos anticorpos da invenção. são também providos imunoconjugados, moléculas biespecíficas e composições farmacêuticas compreendendo os anticorpos da invenção. a invenção também provê métodos para detectar pd-1, bem como métodos para tratamento de várias doenças, incluindo câncer e doenças infecciosas, usando anticorpos anti-pd-1. a presente invenção também provê métodos para emprego de uma imunoterapia de comb
