The disclosure relates to compounds of formula (I)(I),and pharmaceutically acceptable salts, and compositions thereof, wherein the substituents are as defined herein. Also provided are methods of making compounds of formula (I), and methods involving the compounds or compositions for treating disorders and diseases described herein.本發明係關於式(I)化合物(I),及其醫藥上可接受之鹽及組合物,其中該等取代基係如本文中所定義。亦提供製備式(I)化合物之方法,及涉及該等化合物或組合物用於治療本文中所述病症及疾病之方法。