CHROMANE DERIVATIVES AS TRPV3 MODULATORS农业专利-农业学术服务平台

发明人:: LINGAM, V. S. PRASADA RAO,林加姆维萨普拉萨达奥,林加姆維薩普拉薩達奧,THOMAS, ABRAHAM,托马斯亚伯拉罕,托馬斯亞伯拉罕,KHATIK, JAVED YUSUF,卡廷贾维德优素福,卡廷賈維德優素福,KHAIRATKAR-JOSHI, NEELIMA,坎拉特卡乔希尼利马,坎拉特卡喬希尼利馬,KATTIGE, VIDYA GANAP

摘要：: The present invention provides chromane derivatives as transient receptor potential vanilloid (TRPV) modulators. In particular, the compounds described herein are useful for treating or preventing diseases, conditions and/or disorders modulated by TRPV3. Also provided herein are processes for preparing compounds described herein, intermediates used in their synthesis, pharmaceutical compositions thereof, and methods for treating or preventing diseases, conditions and/or disorders modulated by TRPV3.本發明提供了做為暫態受體電位香草素(TRPV)調節劑的色原烷衍生物。特別地,本文所述的化合物可用於治療或預防由TRPV3調節的疾病、病症和/或障礙。同時,本文也提供了製備本文所述的化合物的方法、在其合成中所用的中間體、其藥物組合物以及治療或預防由TRPV3調節的疾病、病症和/或障礙的方法。