作為食慾素受體拮抗劑之脯胺酸磺醯胺衍生物农业专利-农业学术服务平台

发明人:: HEIDMANN, BIBIA,海曼　毕比雅,海曼　畢比雅,BOSS, CHRISTOPH,博斯　克里斯多夫,BROTSCHI, CHRISTINE,布洛奇　克利斯汀,GUDE, MARKUS,古德　马库斯,古德　馬庫斯,GATFIELD, JOHN,加菲欧　约翰,加菲歐　約翰,SIFFERLEN, THIERRY,席佛林　赛瑞,席佛林　賽瑞,WILLIAMS,,海曼毕比雅,海曼畢比雅,博斯克里斯多夫,布洛奇克利斯汀,古德马库斯,古德馬庫斯,加菲欧约翰,加菲歐約翰,席佛林赛瑞,席佛林賽瑞

摘要：: The present invention relates to (S)-proline sulfonamide compounds of formula (I)wherein R1 and R2 are as described in the description, or pharmaceutically acceptable salts thereof, for use in the prevention or treatment of diseases or disorders related to the orexin system. The present invention also relates to the use of (S)-proline sulfonamide compounds of formula (II) as pharmaceuticals, to pharmaceutical compositions comprising compounds of formula (II), and especially their use in the prevention or treatment of diseases or disorders related to the orexin system.本發明係關於式(I)之(S)-脯胺酸磺醯胺化合物，其中R1及R2係如說明書中所述，或其醫藥學上可接受之鹽，其適用於預防或治療與食慾素系統相關之疾病或病症。本發明亦關於式(II)之(S)-脯胺酸磺醯胺化合物作為醫藥劑之用途、包含式(II)化合物之醫藥組合物及尤其其在預防或治療與食慾素系統相關之疾病或病症中的用途。