Provided are antibodies that specifically bind to human histidyl-tRNA synthetase and related therapeutic compositions and methods for treating cancer, including as standalone therapies or in combination with cancer immunotherapies, for example, immune checkpoint modulators such as PD-1 inhibitors.本發明提供特異性結合於人類組胺醯基-tRNA合成酶之抗體及用於治療癌症之相關治療組合物及方法,包括作為獨立療法或與癌症免疫療法組合,癌症免疫療法為例如:免疫檢查點調節劑,諸如PD-1抑制劑。