BUECHLER, YING,CHIANG, KYLE,DO, MINH-HA,LEE, DARIN,PIEHL, KRISTI,THOMAS, MARC,WATKINS, JEFFRY D.,WU, CHI-FANG,MENDLEIN, JOHN D.
申请号：
CA2907046
公开号：
CA2907046A1
申请日:
2014.03.14
申请国别(地区):
CA
年份:
2014
代理人:
摘要：
The present invention provides histidyl-tRNA synthetase and Fc region conjugate polypeptides (HRS-Fc conjugates), such as HRS-Fc fusion polypeptides, compositions comprising the same, and methods of using such conjugates and compositions for treating or diagnosing a variety of conditions. The HRS-Fc conjugates of the invention have improved controlled release properties, stability, half-life, and other pharmacokinetic and biological properties relative to corresponding, unmodified HRS polypeptides.
