PROBLEM TO BE SOLVED: To provide a rapid disintegrating tablet or an intraoral rapid collapsing tablet for preventing deterioration of tablet hardness even when uncomfortable taste such as bitterness in a drug is masked and the tablet is preserved under a high humidity condition for a long period of time.SOLUTION: The rapid disintegrating tablet includes: a first granulated powder (A) containing (a-1) a powder drug including uncomfortable tastes, (a-2) a fluidizing agent preventing aggregation of the powder drug, and (a-3) a carrier for granulating or masking a mixture of the drug and the fluidizing agent and a second granulated powder (B) containing (b-1) at least one granular base component having the average particle diameter of 10-500 &mum that is selected from saccharide, sugar alcohol and amino acid, (b-2) a disintegrant having &le1.3 swelling ratio in water absorption, and (b-3) a water-soluble binding agent, wherein the content of (b-3) the water-soluble binding agent is &le1 pts.wt. based on 100 pts.wt. of tablets.COPYRIGHT: (C)2012,JPO&INPIT【課題】薬物の不快な呈味(苦味など)をマスキングし、高湿度下で長期間に亘り保存しても錠剤硬度の低下を抑制できる速崩壊錠(又は口腔内速崩錠)、及びその製造方法を提供する。【解決手段】速崩壊錠は、(a-1)不快な呈味を有する粉末状薬物、(a-2)粉末状薬物の凝集を抑制する流動化剤、及び(a-3)前記薬物と流動化剤との混合物を造粒又は被覆するための担体とを含む第1の顆粒(A)と、(b-1)平均粒子径10~500μmを有し、かつ糖、糖アルコール及びアミノ酸から選択された少なくとも一種の粒状ベース成分、(b-2)吸水時の膨潤率が1.3以下の崩壊剤、及び(b-3)水溶性結合剤を含有し、(b-3)前記水溶性結合剤の含有量が錠剤100重量部に対して1重量部以下である第2の顆粒(B)とを含む。【選択図】なし
