We disclose a cell-based olfactory sensing device which may be used to diagnose diseases that a mammal, insect, or other organism may diagnose by smell. The device includes a multi-well cell culture plate which cultivates a plurality of cell lines. The cell lines each express a heterologously expressed olfactory receptor gene and a reporter gene. When a ligand from a biological sample derived from a user binds one or more of the olfactory receptors expressed by the cell lines, the reporter genes are expressed. The product of the reporter genes is detectable. Furthermore, the device may be part of a medical toilet. The device may include a controller which may include a memory and a machine-readable medium for analyzing data the device collects.
