The Trustees of Columbia University in the City of New York
发明人:
申请号：
EP16815487.0
公开号：
EP3313416A4
申请日:
2016.06.27
申请国别(地区):
EP
年份:
2019
代理人:
摘要：
Provided herein are insulin-negative cells that have been genetically modified to report expression of one or more target genes. Exemplified are reporter cell lines that provide a readout of Ngn3, Foxo1 or Tph2 expression. Reporter cells are used to screen for agents that affect expression of one or more of these genes to identify agents capable of converting gut progenitor cells to insulin-positive cells.
