Antigen-binding molecule that promotes disappearance of antigen via FcγRIIB

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专利权人:

中外製薬株式会社

发明人:

井川 智之,前田 敦彦,岩柳 有起,原谷 健太,堅田 仁,門野 正次郎,味元 風太

申请号：

JP2014500939

公开号：

JP6138108B2

申请日:

2013.02.22

申请国别(地区):

JP

年份:

2017

代理人:

摘要：

The present invention provides antigen-binding molecules containing (i) an antigen-binding domain whose antigen-binding activity varies depending on ion concentration conditions, (ii) an Fc³-binding domain having Fc³ RIIb-selective binding activity, and (iii) an FcRn-binding domain having FcRn-binding activity under an acidic pH range condition, and methods of decreasing plasma antigen concentration as compared to before administering the molecule, which include the step of administering the molecule.

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